Delta-like 1

DLL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4XBM
Identifiers
Aliases	DLL1, DELTA1, DL1, Delta, Delta-like 1, delta like canonical Notch ligand 1, NEDBAS
External IDs	OMIM: 606582; MGI: 104659; HomoloGene: 4104; GeneCards: DLL1; OMA:DLL1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6q27 Start 170,282,206 bp End 170,306,565 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17 A2|17 8.95 cM Start 15,587,616 bp End 15,597,134 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen ventricular zone skin of abdomen skin of leg prostate apex of heart mucosa of esophagus vagina right auricle of heart minor salivary glands Top expressed in paraxial mesoderm tail of embryo ventricular zone primitive streak ciliary body tongue muscle corneal stroma ganglionic eminence medial ganglionic eminence right lung More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding scaffold protein binding Tat protein binding Notch binding protein binding Cellular component integral component of membrane membrane adherens junction plasma membrane integral component of plasma membrane extracellular region cell junction apical plasma membrane membrane raft cytoplasmic vesicle Biological process Notch signaling pathway somitogenesis negative regulation of interleukin-10 production proximal/distal pattern formation cell differentiation negative regulation of myoblast differentiation organ growth regulation of somitogenesis regulation of cell division negative regulation of neuron differentiation loop of Henle development negative regulation of inner ear auditory receptor cell differentiation astrocyte development somite specification negative regulation of glial cell apoptotic process negative regulation of cell differentiation neuron fate specification endothelial tip cell fate specification cell-cell signaling regulation of skeletal muscle tissue growth marginal zone B cell differentiation skeletal muscle tissue growth lateral inhibition regulation of vascular endothelial growth factor signaling pathway neuronal stem cell population maintenance positive regulation of sprouting angiogenesis regulation of blood pressure heart looping cerebellar molecular layer formation cell communication positive regulation of endocytosis retina morphogenesis in camera-type eye proximal tubule development negative regulation of epidermal cell differentiation clathrin-dependent endocytosis determination of left/right symmetry regulation of cell adhesion cerebellar Purkinje cell layer structural organization compartment pattern specification positive regulation of gene expression retina development in camera-type eye skin epidermis development positive regulation of cell population proliferation nephron development spinal cord development cell fate determination inner ear development multicellular organism development regulation of growth Notch signaling pathway involved in arterial endothelial cell fate commitment type B pancreatic cell development negative regulation of epithelial cell differentiation negative regulation of myeloid cell differentiation positive regulation of skeletal muscle tissue growth regulation of neurogenesis left/right axis specification positive regulation of Notch signaling pathway negative regulation of cell population proliferation positive regulation of transcription by RNA polymerase II negative regulation of cardiac muscle cell differentiation hemopoiesis energy homeostasis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 28514 13388 Ensembl ENSG00000275555 ENSG00000198719 ENSMUSG00000014773 UniProt O00548 Q61483 RefSeq (mRNA) NM_005618 NM_007865 NM_001379042 RefSeq (protein) NP_005609 NP_031891 NP_001365971 Location (UCSC) Chr 6: 170.28 – 170.31 Mb Chr 17: 15.59 – 15.6 Mb PubMed search
Wikidata
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Delta-like protein 1 is a protein that in humans is encoded by the DLL1 gene.

Function

DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication.

Summary

DLL1 (Delta-like canonical Notch ligand 1) is a transmembrane protein that serves as a ligand in the Notch signaling pathway, which is crucial for cell fate determination during embryonic development. DLL1 is essential for the formation of somites, the segmented precursors to the vertebral column and skeletal muscles. In mouse models, the absence of DLL1 leads to disrupted somite formation and embryonic lethality, highlighting its vital role in mesodermal segmentation. Beyond somitogenesis, DLL1-mediated Notch signaling is critical for establishing left–right asymmetry in the developing embryo by regulating the expression of the Nodal gene. Mutations in DLL1 can result in defects in this asymmetry, leading to congenital anomalies. Furthermore, DLL1 haploinsufficiency in humans has been associated with neurodevelopmental disorders, including microcephaly and hydrocephalus, due to impaired Notch signaling during brain development.

The multifaceted roles of DLL1 in embryonic development underscore its importance in proper organogenesis and highlight the consequences of its dysregulation in human disease.

Interactions

Delta-like 1 has been shown to interact with NOTCH2.

Further reading

• Watt FM (2002). "The stem cell compartment in human interfollicular epidermis". J. Dermatol. Sci. 28 (3): 173–80. doi:10.1016/S0923-1811(02)00003-8. PMID 11912004.
• Lewis AK, Frantz GD, Carpenter DA, de Sauvage FJ, Gao WQ (1999). "Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear". Mech. Dev. 78 (1–2): 159–63. doi:10.1016/S0925-4773(98)00165-8. PMID 9858718. S2CID 9675950.
• Mitsiadis TA, Hirsinger E, Lendahl U, Goridis C (1999). "Delta-notch signaling in odontogenesis: correlation with cytodifferentiation and evidence for feedback regulation". Dev. Biol. 204 (2): 420–31. doi:10.1006/dbio.1998.9092. PMID 9882480.
• Gray GE, Mann RS, Mitsiadis E, Henrique D, Carcangiu ML, Banks A, Leiman J, Ward D, Ish-Horowitz D, Artavanis-Tsakonas S (1999). "Human Ligands of the Notch Receptor". Am. J. Pathol. 154 (3): 785–94. doi:10.1016/S0002-9440(10)65325-4. PMC 1866435. PMID 10079256.
• Beckers J, Clark A, Wünsch K, Hrabé De Angelis M, Gossler A (1999). "Expression of the mouse Delta1 gene during organogenesis and fetal development". Mech. Dev. 84 (1–2): 165–8. doi:10.1016/S0925-4773(99)00065-9. PMID 10473134. S2CID 15047523.
• Morrison A, Hodgetts C, Gossler A, Hrabé de Angelis M, Lewis J (1999). "Expression of Delta1 and Serrate1 (Jagged1) in the mouse inner ear". Mech. Dev. 84 (1–2): 169–72. doi:10.1016/S0925-4773(99)00066-0. PMID 10473135. S2CID 17955906.
• Han W, Ye Q, Moore MA (2000). "A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells". Blood. 95 (5): 1616–25. doi:10.1182/blood.V95.5.1616.005k31_1616_1625. PMID 10688816.
• Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2". Mol. Cell. Biol. 20 (18): 6913–22. doi:10.1128/MCB.20.18.6913-6922.2000. PMC 88767. PMID 10958687.
• Shimizu K, Chiba S, Saito T, Kumano K, Hirai H (2000). "Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors". Biochem. Biophys. Res. Commun. 276 (1): 385–9. doi:10.1006/bbrc.2000.3469. PMID 11006133.
• Jaleco AC, Neves H, Hooijberg E, Gameiro P, Clode N, Haury M, Henrique D, Parreira L (2001). "Differential Effects of Notch Ligands Delta-1 and Jagged-1 in Human Lymphoid Differentiation". J. Exp. Med. 194 (7): 991–1002. doi:10.1084/jem.194.7.991. PMC 2193482. PMID 11581320.
• Shimizu K, Chiba S, Saito T, Takahashi T, Kumano K, Hamada Y, Hirai H (2002). "Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain". EMBO J. 21 (3): 294–302. doi:10.1093/emboj/21.3.294. PMC 125840. PMID 11823422.
• Panin VM, Shao L, Lei L, Moloney DJ, Irvine KD, Haltiwanger RS (2002). "Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe". J. Biol. Chem. 277 (33): 29945–52. doi:10.1074/jbc.M204445200. PMID 12036964.
• Sakamoto K, Yamaguchi S, Ando R, Miyawaki A, Kabasawa Y, Takagi M, Li CL, Perbal B, Katsube K (2002). "The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway". J. Biol. Chem. 277 (33): 29399–405. doi:10.1074/jbc.M203727200. PMID 12050162.
• Ohishi K, Varnum-Finney B, Bernstein ID (2002). "Delta-1 enhances marrow and thymus repopulating ability of human CD34+CD38– cord blood cells". J. Clin. Invest. 110 (8): 1165–74. doi:10.1172/JCI16167. PMC 150801. PMID 12393852.
• Karlström H, Beatus P, Dannaeus K, Chapman G, Lendahl U, Lundkvist J (2003). "A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 17119–24. doi:10.1073/pnas.252624099. PMC 139279. PMID 12482954.
• Tohda S, Murata-Ohsawa M, Sakano S, Nara N (2003). "Notch ligands, Delta-1 and Delta-4 suppress the self-renewal capacity and long-term growth of two myeloblastic leukemia cell lines". Int. J. Oncol. 22 (5): 1073–9. doi:10.3892/ijo.22.5.1073. PMID 12684674.
• Six E, Ndiaye D, Laabi Y, Brou C, Gupta-Rossi N, Israel A, Logeat F (2003). "The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and γ-secretase". Proc. Natl. Acad. Sci. U.S.A. 100 (13): 7638–43. Bibcode:2003PNAS..100.7638S. doi:10.1073/pnas.1230693100. PMC 164639. PMID 12794186.
• LaVoie MJ, Selkoe DJ (2003). "The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments". J. Biol. Chem. 278 (36): 34427–37. doi:10.1074/jbc.M302659200. PMID 12826675.