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Stuart Conway
[edit]Stuart J. Conway FRSC is a British chemist specializing in medicinal chemistry and chemical biology. He currently holds the Michael and Alice Jung Endowed Chair in Medicinal Chemistry and Drug Discovery at the University of California, Los Angeles (UCLA).[1] Conway is a member of the California NanoSystems Institute (CNSI),[2] the UCLA Institute of Molecular Biology,[3] and the Jonsson Comprehensive Cancer Center.[4]
Education and Early Career
[edit]Conway completed his undergraduate studies in Chemistry with Medicinal Chemistry at the University of Warwick between 1994 and 1997, where he conducted an undergraduate research project with Professor Andrew Clark. He then pursued his Ph.D. at the University of Bristol from 1997 to 2001, working with Professors Jeff Watkins FRS and David Jane. Following his doctorate, Conway undertook postdoctoral research with Professor Andrew Holmes FRS at the University of Cambridge from 2001 to 2003.
Academic Appointments
[edit]In 2003, Conway began his independent academic career as a Lecturer in Bioorganic Chemistry at the University of St Andrews. He joined the University of Oxford in 2008 as an Associate Professor and was promoted to Full Professor in 2014. During his tenure at Oxford, he also served as the E. P. Abraham Cephalosporin Fellow in Organic Chemistry at St Hugh's College, Oxford. In 2023, Conway moved to UCLA, where he was appointed the inaugural holder of the Michael and Alice Jung Endowed Chair in Medicinal Chemistry and Drug Discovery.
Research Focus
[edit]Conway’s research focuses on the development of molecular tools to study biological systems, particularly in the fields of epigenetics, hypoxia, and targeted protein degradation. His lab has made significant contributions to the understanding of cancer biology by designing small molecules that modulate epigenetic targets and hypoxia-inducible factors. His group reported inhibitors of the BET-bromodomain-containing proteins,[5] the CREBBP and P300 bromodomains,[6] and developed hypoxia-targeted pro-drugs[7] and probes for imaging hypoxia in cells.[8]
Affiliations
[edit]- UCLA Department of Chemistry & Biochemistry
- California NanoSystems Institute (CNSI)
- UCLA Institute of Molecular Biology
- Jonsson Comprehensive Cancer Center
Awards and Honors
[edit]Throughout his career, Conway has received a number of prestigious awards, including:
- The European Federation for Medicinal Chemistry Prize for a Young Medicinal Chemist (2012)[9]
- The UCB-Ehrlich Award from the European Federation for Medicinal Chemistry (2024)[10]
- The Robert M. Scarborough Award for Excellence in Medicinal Chemistry from the American Chemical Society Division of Medicinal Chemistry (2024)[11]
Professional Service
[edit]Conway has held several leadership roles within the scientific community, including:
- President of the Royal Society of Chemistry Organic Division (2019–2022)[12]
- Associate Editor for the Journal of Medicinal Chemistry (2016–2024)
- Associate Editor for ACS Bio & Med Chem Au (2021–2024)
- Member of the European Federation for Medicinal Chemistry Advisory Board (2016–2018)
- Treasurer of the American Chemical Society Division of Medicinal Chemistry (2024-present)[13]
External Links
[edit]- UCLA Department of Chemistry and Biochemistry Profile: https://www.chemistry.ucla.edu/directory/conway-stuart-j/
- Conway Group Website: https://sites.google.com/view/conwaygroup/team/stuart?authuser=0
- Stuart Conway’s Google Scholar Profile: https://scholar.google.co.uk/citations?hl=en&user=43nrsFUAAAAJ
- California NanoSystems Institute (CNSI): https://cnsi.ucla.edu/
- UCLA Institute of Molecular Biology: https://www.mbi.ucla.edu/
- Jonsson Comprehensive Cancer Center: https://www.uclahealth.org/cancer
References
[edit]- ^ Jennings, Penny. "Endowed Chairs: Ensuring Faculty Excellence".
- ^ "Members - California NanoSystems Institute". 2017-07-11. Retrieved 2025-04-29.
- ^ "Faculty – Molecular Biology Institute". Retrieved 2025-04-29.
- ^ "Stuart Conway, PhD - Member Directory | UCLA Health Jonsson Comprehensive Cancer Center". www.uclahealth.org. Retrieved 2025-04-29.
- ^ Hewings, David S.; Fedorov, Oleg; Filippakopoulos, Panagis; Martin, Sarah; Picaud, Sarah; Tumber, Anthony; Wells, Christopher; Olcina, Monica M.; Freeman, Katherine; Gill, Andrew; Ritchie, Alison J.; Sheppard, David W.; Russell, Angela J.; Hammond, Ester M.; Knapp, Stefan (2013-04-25). "Optimization of 3,5-Dimethylisoxazole Derivatives as Potent Bromodomain Ligands". Journal of Medicinal Chemistry. 56 (8): 3217–3227. doi:10.1021/jm301588r. ISSN 0022-2623. PMC 3640414. PMID 23517011.
- ^ Rooney, Timothy P. C.; Filippakopoulos, Panagis; Fedorov, Oleg; Picaud, Sarah; Cortopassi, Wilian A.; Hay, Duncan A.; Martin, Sarah; Tumber, Anthony; Rogers, Catherine M.; Philpott, Martin; Wang, Minghua; Thompson, Amber L.; Heightman, Tom D.; Pryde, David C.; Cook, Andrew (2014). "A Series of Potent CREBBP Bromodomain Ligands Reveals an Induced-Fit Pocket Stabilized by a Cation–π Interaction". Angewandte Chemie International Edition. 53 (24): 6126–6130. doi:10.1002/anie.201402750. ISSN 1521-3773. PMC 4298791. PMID 24821300.
- ^ Skwarska, Anna; Calder, Ewen D. D.; Sneddon, Deborah; Bolland, Hannah; Odyniec, Maria L.; Mistry, Ishna N.; Martin, Jennifer; Folkes, Lisa K.; Conway, Stuart J.; Hammond, Ester M. (2021-09-16). "Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor". Cell Chemical Biology. 28 (9): 1258–1270.e13. doi:10.1016/j.chembiol.2021.04.004. ISSN 2451-9456. PMID 33910023.
- ^ Wallabregue, Antoine L. D.; Bolland, Hannah; Faulkner, Stephen; Hammond, Ester M.; Conway, Stuart J. (2023-02-01). "Two Color Imaging of Different Hypoxia Levels in Cancer Cells". Journal of the American Chemical Society. 145 (4): 2572–2583. doi:10.1021/jacs.2c12493. ISSN 0002-7863. PMC 9896549. PMID 36656915.
- ^ "The EFMC Prizes for Young Medicinal Chemists". www.efmc.info. Retrieved 2025-04-29.
- ^ "The UCB-Ehrlich Award for Excellence in Medicinal Chemistry". www.efmc.info. Retrieved 2025-04-29.
- ^ "The Robert M. Scarborough Award". www.acsmedchem.org. Retrieved 2025-04-29.
- ^ "About the Organic Chemistry Community". Royal Society of Chemistry. Retrieved 2025-04-29.
- ^ "Regular Executive Committee Members". www.acsmedchem.org. Retrieved 2025-04-29.