GPR88

GPR88
Identifiers
Aliases	GPR88, STRG, COCPMR, G protein-coupled receptor 88
External IDs	OMIM: 607468; MGI: 1927653; HomoloGene: 11104; GeneCards: GPR88; OMA:GPR88 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	100,542,021 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	116,047,152 bp
RNA expression pattern
	Top expressed in
	external globus pallidus; ; putamen; ; caudate nucleus; ; nucleus accumbens; ; endothelial cell; ; entorhinal cortex; ; middle temporal gyrus; ; prefrontal cortex; ; right lobe of liver; ; dorsolateral prefrontal cortex;
	Top expressed in
	olfactory tubercle; ; globus pallidus; ; nucleus accumbens; ; superior frontal gyrus; ; lateral septal nucleus; ; piriform cortex; ; lumbar subsegment of spinal cord; ; Temporal Lobe; ; barrel cortex; ; primary visual cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; cytoskeletal motor activity; G protein-coupled receptor activity; G protein-coupled photoreceptor activity;
Cellular component	integral component of membrane; membrane; nucleus; cytoplasm; plasma membrane; cellular component; integral component of plasma membrane; cilium;
Biological process	locomotory behavior; neuromuscular process controlling balance; neuronal action potential; signal transduction; motor learning; G protein-coupled receptor signaling pathway; neuropeptide signaling pathway; chemical synaptic transmission; feeding behavior; phototransduction; detection of visible light; cellular response to light stimulus;
	Sources:Amigo / QuickGO
Orthologs
	54112
	64378
	ENSG00000181656
	ENSMUSG00000068696
	Q9GZN0
	Q9EPB7
	NM_022049
	NM_022427
	NP_071332
	NP_071872
	Wikidata
View/Edit Human	View/Edit Mouse

Probable G-protein coupled receptor 88 is a protein that in humans is encoded by the GPR88 gene.^[5]^[6]^[7]^[8]^[9]

Ligands

Agonists

RTI-122 ^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000181656 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000068696 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
^ Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
^ Mizushima K, Miyamoto Y, Tsukahara F, et al. (2001). "A novel G-protein-coupled receptor gene expressed in striatum". Genomics. 69 (3): 314–21. doi:10.1006/geno.2000.6340. PMID 11056049.
^ Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
^ Van Waes V, Tseng K, Steiner H (2011). "GPR88 - a putative signaling molecule predominantly expressed in the striatum: Cellular localization and developmental regulation". Basal Ganglia. 1 (2): 83–89. doi:10.1016/j.baga.2011.04.001. PMC 3144573. PMID 21804954.
^ Rahman MT, Decker AM, Ben Hamida S, Perrey DA, Chaminda Lakmal HH, Maitra R, Darcq E, Kieffer BL, Jin C. Improvement of the Metabolic Stability of GPR88 Agonist RTI-13951-33: Design, Synthesis, and Biological Evaluation. J Med Chem. 2023 Feb 23;66(4):2964-2978. doi:10.1021/acs.jmedchem.2c01983 PMID 36749855

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000181656 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000068696 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

[6] Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.

[7] Mizushima K, Miyamoto Y, Tsukahara F, et al. (2001). "A novel G-protein-coupled receptor gene expressed in striatum". Genomics. 69 (3): 314–21. doi:10.1006/geno.2000.6340. PMID 11056049.

[8] Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[9] Van Waes V, Tseng K, Steiner H (2011). "GPR88 - a putative signaling molecule predominantly expressed in the striatum: Cellular localization and developmental regulation". Basal Ganglia. 1 (2): 83–89. doi:10.1016/j.baga.2011.04.001. PMC 3144573. PMID 21804954.

[10] Rahman MT, Decker AM, Ben Hamida S, Perrey DA, Chaminda Lakmal HH, Maitra R, Darcq E, Kieffer BL, Jin C. Improvement of the Metabolic Stability of GPR88 Agonist RTI-13951-33: Design, Synthesis, and Biological Evaluation. J Med Chem. 2023 Feb 23;66(4):2964-2978. doi:10.1021/acs.jmedchem.2c01983 PMID 36749855

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