U2OS cell line
U2OS is the name of a partially differentiated human osteosarcoma (OS) cell line[1]. U2OS cells were derived from the tibial bone of a 15-year-old female patient with osteosarcoma by scientists Dr. Jeroen Ponten (affiliated with Catharina Ziekenhuis[2]) and Dr. Eero Saksela (affiliated with University of Helsinki at the time[3]) in 1964[4].
U2OS cells exhibit epithelial morphology, meaning that they still maintain some of their epithelial properties, despite being cancerous in nature. Some of these properties can include having organized layers, distinct cellular boundaries, and possessing tight junctions.
U2OS cells have been used in used in cancer research, drug development, apoptosis studies, genetic research, and radiation oncology studies.
- ^ "Cellosaurus U2OS (CVCL_0042)". Cellosaurus. 2025-04-10. Retrieved 2025-04-28.
{{cite web}}: CS1 maint: url-status (link) - ^ "Jeroen PONTEN | Medical Doctor | Doctor of Philosophy | Catharina Ziekenhuis, Eindhoven | Department of Surgery | Research profile". ResearchGate. Archived from the original on 2023-02-19. Retrieved 2025-04-29.
- ^ "Eero Saksela". www.wikidata.org. Retrieved 2025-04-29.
- ^ Ponten, Jan; Saksela, Eero (1967). "Two established in vitro cell lines from human mesenchymal tumours". International Journal of Cancer. 2 (5): 434–447. doi:10.1002/ijc.2910020505. ISSN 1097-0215.